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The Journal of Antibiotics
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The Journal of Antibiotics
Article . 1975 . Peer-reviewed
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The Journal of Antibiotics
Article . 1975
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The Journal of Antibiotics
Article
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Stability studies with amphotericin B and amphotericin B methyl ester.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1975 English Publisher:Japan Antibiotics Research AssociationJournal:The Journal of Antibiotics, volume 28, pages 132-135 (issn: 0021-8820, eissn: 1881-1469, Copyright policy )
Authors: Carl P. Schaffner; Daniel P. Bonner; Witold Mechlinski;

doi: 10.7164/antibiotics.28.132

pmid: 234414

Stability studies with amphotericin B and amphotericin B methyl ester.

Abstract

In solid form, amphotericin B and amphotericin B methyl ester free base exhibit similar stability. Acid salts of the methyl ester derivative stored under identical conditions are less stable. In solution, amphotericin B is generally more stable than its methy ester salts. However, when pH is adjusted to 6.0 and storage temperature held at 5 degrees C the methyl ester salts reflect the stability exhibited by the parent compound, amphotericin B.

Related Organizations
Keywords

Time Factors, Drug Stability, Solubility, Amphotericin B, Temperature, Esters, Saccharomyces cerevisiae, Hydrogen-Ion Concentration

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    citations
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    		 32
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
32
Average
Top 10%
Top 10%
bronze