Kisspeptin/KISS1R System in Breast Cancer

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 01 Jan 2013 English Publisher:Ivyspring International PublisherJournal:Journal of Cancer, volume 4, pages 653-661 (issn: 1837-9664,

Copyright policy )Funded by:NSERC | unidentified, CIHR | unidentified

Authors: Cvetković, Donna; Babwah, Andy V.; Bhattacharya, Moshmi;

doi: 10.7150/jca.7626

pmid: 24155777

pmc: PMC3805993

Kisspeptin/KISS1R System in Breast Cancer

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Abstract

Kisspeptins (KP), peptide products of the kisspeptin-1 (KISS1) gene are the endogenous ligands for a G protein-coupled receptor (GPCR) - KP receptor (KISS1R). KISS1R couples to the Gαq/11 signaling pathway. KISS1 is a metastasis suppressor gene and the KP/KISS1R signaling has anti-metastatic and tumor-suppressant effects in numerous human cancers. On the other hand, recent studies indicate that KP/KISS1R pathway plays detrimental roles in breast cancer. In this review, we summarize recent developments in the understanding of the mechanisms regulating KP/KISS1R signaling in breast cancer metastasis.

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