Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1
Copyright policy )Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1
Human tumor suppressor gene RIZ encodes two protein products, tumor suppressor RIZ1 and proto-oncoprotein RIZ2, which regulate cellular functions in a Yin-Yang fashion. The only structural difference between them is that RIZ2 lacks the N-terminal PR domain. In this study, we showed that RIZ1 mRNA expression level was elevated in stage IV of eight different types of cancer (stage III for prostate cancer), indicating that RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity.
- Saskatchewan Science Centre Canada
- University of Saskatchewan Canada
Male, Sequence Homology, Amino Acid, Tumor Suppressor Proteins, Molecular Sequence Data, Nuclear Proteins, Antineoplastic Agents, Histone-Lysine N-Methyltransferase, Peptide Fragments, Protein Structure, Tertiary, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Neoplasms, Tumor Cells, Cultured, Humans, Female, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Transcription Factors
Male, Sequence Homology, Amino Acid, Tumor Suppressor Proteins, Molecular Sequence Data, Nuclear Proteins, Antineoplastic Agents, Histone-Lysine N-Methyltransferase, Peptide Fragments, Protein Structure, Tertiary, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Neoplasms, Tumor Cells, Cultured, Humans, Female, Amino Acid Sequence, RNA, Messenger, Cloning, Molecular, Transcription Factors
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