The study presents a prototype framework for integrated analysis aimed at assessing socioeconomic and demographic profiles in Sites of National Interest (SIN), applied to the Sulcis-Iglesiente-Guspinese SIN site (in south-western Sardinia). The developed model combines demographic, economic, educational attainment, employment data and is structured on two territorial levels: sub-municipal, through the aggregation of enumeration areas, and supra-municipal, through clusters of municipalities, to represent different scales of pollutant exposure. The findings support the creation of spatial profiles to assist territorial planning and policymaking aimed at reducing social and health inequalities.