The implications of a serious disease outbreak extend well beyond the disease itself. The levels of sickness and mortality, while important, can be quickly overshadowed by cascading risk implications that affect the global economy, threaten societal confidence, weaken the rule of law, present a risk to food security, and can lead to inter- and intra-state conflict. When multiple countries are concurrently impacted, the provision of life-saving and time-sensitive aid and humanitarian assistance can also be affected, leading to isolation and a domino effect of collapsing societies. When nations start from a low baseline level of resilience, then the speed of government and infrastructure failure may be swift. Resilience across every facet of government, community and business is critical if the disruptive effects of the disease and the more far-reaching effects of the fear the unseen enemy creates are to be controlled. This article describes the interconnected risks and impacts found within a pandemic crisis and how COVID-19 can impact every facet of society and business — providing the backdrop against which risk practitioners can contextualise how their respective organisations can plan for, respond to, manage, and ultimately recover from a pandemic crisis.