Background: Patient safety and quality improvement are critical pillars of modern healthcare, essential for minimizing preventable harm and enhancing care delivery. Despite global attention, healthcare-associated adverse events remain a significant cause of patient morbidity and mortality, underscoring the need for robust, integrated systems. Aim: This review aims to synthesize evidence on effective strategies for enhancing patient safety and healthcare quality. It explores the interconnected roles of health administration, informatics, clinical maintenance, and security, advocating for a multidisciplinary approach to systemic improvement. Methods: A comprehensive literature review was conducted, analyzing studies on interventions such as staff training, technology integration, safety culture initiatives, and standardized protocols. The review examined outcomes across various healthcare settings, focusing on clinical results, process reliability, and organizational performance. Results: The findings demonstrate that effective safety and quality improvements are multifaceted. Key successful strategies include structured training (e.g., simulation, interprofessional education), strong leadership engagement, the implementation of a "Just Culture," and the adoption of health information technologies. Standardized protocols, particularly for medication safety and antimicrobial stewardship, significantly reduce errors. Furthermore, initiatives focusing on cultural safety and equitable care are vital for addressing the needs of diverse populations. Conclusion: A synergistic approach that integrates education, technology, leadership, and a supportive organizational culture is paramount for advancing patient safety and healthcare quality. Sustained improvement requires continuous, system-wide commitment to these evidence-based strategies.