
doi: 10.62791/20515
Two important aspects of skin wound healing are maintaining a clean, moist wound environment, and preventing infection. An effective skin wound dressing protects the wound from external debris, helps maintain a healthy wound environment, and does not damage the tissue. Hydrogels are a commonly used skin wound dressing material due to their nonadherent nature, biocompatibility, swell ability, similarity in mechanical strength to skin, and tunability of properties. These properties can be affected by phase changes, or conformation of the polymer components of the hydrogel in response to stimuli such as pH or temperature. Additionally, antibacterial agents can be incorporated into the hydrogel to prevent or treat bacterial infection. In this study I explored a thermoresponsive hydrogel skin wound dressing using chitosan and PNIPAM that is potentially able to undergo phase transition to elute an antibacterial drug at the increased temperature of wounded skin, then stop drug elution once the skin has healed and the skin temperature returns to the normal baseline. The resulting hydrogel was shown to be capable of successful thermal phase transition and drug elution, and was significantly weaker than healthy human skin while maintaining a stiffness that was higher than healthy human skin.
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