Keratinocyte cancer (KC) cases have risen by 172% in Denmark over the last decade and the lifetime risk of developing KC is at least 22%. This highlights the need for innovative strategies in KC prevention, diagnosis, and treatment. To reduce incidence, new prevention methods are crucial. New diagnostics using non-invasive scanning can streamline patient care, especially for low-risk tumours and patients with multiple tumours. New treatments can be more effective and with fewer side effects. Together, these initiatives can improve the patient journey and ease the burden on healthcare resources, as argued in this review.