This article describes the design of a high cadence laser micro-drilling machine for the manufacture of large micro-drilled panels, which will form part of the leading edge of tail stabilisers on future commercial aircraft. This type of microperforated surface will be of great interest mainly in the aeronautical field, since it will improve the aerodynamic performance of the aircrafts supposing a fuel saving of up to 10 %. Manufacturing requirements demand through-holes of around 0.1 mm at a cadence equal to or greater than 300 holes per second. The quality of each of the holes, as well as the precision of the distance between them has been decisive in the design phase. The machine will be equipped with on-site measurement and defect detection systems to ensure the quality of the holes. Keywords: microdrilling, laser, titanium, machine, HLFC