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https://doi.org/10.6028/jres.0...
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Amides of glucuronic, galacturonic, and mannuronic acids

Authors: Harriet L. Frush; Horace S. Isbell;

Amides of glucuronic, galacturonic, and mannuronic acids

Abstract

Heretofore the amides of glucuronic, galacturonic, and mannuronic acid were not known, and methods were not available for their preparation. It has now been found possible to obtain the amides of uronic acids from the corresponding 1-amino-uronamides by selective hydrolysis of the glycosylamino group. An aqueous solution of the 1-amino-uronamide is treated with an acid or a suitable cation exchange resin that replaces the glycosylamino group by a hydroxyl, forming the free amide. The new compounds, like the sugars, have a free reducing group, and hence they are capable of existing in the pyranose, furanose, and open-chain forms and of displaying mutarotation. D-Glucuronamide, D-mannuronamide, and D-galacturonamide were separated in the alpha pyranose form. The beta pyranose modification of D-galacturonamide was also obtained. The amides are stable crystalline substances, that should prove to.be useful representatives of a new class of carbohydrate derivatives.

Keywords

Hexuronic Acids, Anesthetics, Local, Amides

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    9
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    influence
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Average
Top 10%
Average
bronze