Pulp capping materials posses a vital role in in maintain structural integrity of tooth. Ca++/OHrelease which often play a pivotal role are often ignored. To ensure all the properties are given equal importance, this systematic review was conducted to select the pulp capping agent which fulfils all the properties required for a successful clinical outcome.This review insights common clinician for selecting a material during deep carious management.The aim of this review is to select the best pulp capping material that satisfies all the requirements of physical, chemical and biological properties that are beneficial for pulp therapy.Protocol was formulated in accordance with PRISMA checklist 2020 and registered on PROSPERO (CRD42020160461). Electronic search from databases such as Medline/PubMed, Google Scholar, and Cochrane were performed from the year 2008– 2023. In Vitro studies that evaluated chemical, physical, mechanical and biological properties of pulp capping agents were included. A total of 15 studies were included in the systematic review. After assessing the risk of bias using Newcastle-Ottawa Scale, data was compiled of the included studies. A total of 3038 articles were retrieved from selected databases and out of which 15 studies were included in this review. Based on the risk of bias assessment 2 studies were of very good quality, 5 studies of good quality and 8 studies were of satisfactory quality. Among the pulp capping agents, Tech Biosealer capping, MTA Plus gel and Biodentine exhibited high values of Calcium ion release both at short (3 days) and long-time interval (28 days) whereas Lime-Lite released least amount of Calcium ions. Biodentine had the highest compressive strength and is most cytocompatible. This review leads to the conclusion that calcium silicate-based materials demonstrate superior chemical, physico-mechanical and biological properties, closely aligning with the desirable attributes for pulp therapy. Out of the Calcium silicate-based materials Biodentine exhibits properties that are best for pulpal healing.