Nucleic acids are major biological molecules essential for life, and everyday, there are large number of nucleic acids sequences that are released and searched. Now, many nucleic acids databases were used to assembly and distribute structural information related nucleic acids on the internet. In order to find or submit quickly needed nucleic acids sequences, this present paper introduced seven popular nucleic acids databases, including EMBL-Bank (European Molecular Biology Laboratory Nucleotide Sequence Database), GenBank, DDBJ (DNA Data Bank of Japan), GDB (Human Genome Database), EID (Exon-Intron Dabase), EPD (Eukaryotic Promoter Data) and RNAiDB (RNA Interference Database). KeywordsNucleic Acids; Database; Sequence; Submission And Search