The present research aims at evaluating the health-related quality of life in sixty adult patients of both genders with a diagnosis of Epilepsy, in the city of Medellin, Colombia. The study design was explora-tory-descriptive-transversal. The specific questionnaire INCAVI-72 that measures health-related qual-ity of life for patients with Epilepsy, was used. The results demonstrate a health-related quality of life within normal limits of the subscales of: state of health and daily activities, satisfaction, social support, adverse effects of medication, impact of the epilepsy, and with low scores in the subscales of: evalua-tion of feelings, and control of the INCAVI-72 questionnaire. Cronbach's alfa of the questionnaire IN-CAVI-72 was found to be 0,70. In conclusion, the emotional state and the personal control are relevant factors in the health-related quality of life of the patients with epilepsy.