Introduction: Calcific tendinopathy (CT) of the shoulder is frequently a painful condition that is occurring when there are calcium deposits in the tendons of the rotator cuff. There are many options for treatment starting from therapeutic options like medicaments, physical therapy and radial extracorporeal shock wave therapy (rESWT). If conservative treatment fails, surgical treatment is the next option. The purpose of this study was to investigate the outcome effect of rESWT in patients with calcific tendinopathy. Methods: A prospective study from February 2010 to March 2019 monitored 67 patients with CT of the shoulders of the average age of 47.06 ± 15.2 (mean± standard deviation) who were treated with a rESWT. All patients were evaluated clinically with selected radiographic evaluation of the shoulder before therapeutic intervention. The treatment protocol consisted of a sound pressure intensity of 3 bar, a wave frequency of 14/sec, a total of 2,000 waves per session. All patients performed a treatment consisting of three sessions described every seven days. The outcome parameters were VAS scale of pain and shoulder radiography before and after therapy. The Student's t-test was used in the statistical analysis. Results: Clinical and radiographic improvement was recorded in 70% of patients in the treatment of CT of the shoulder 6 weeks after the therapy was performed with a rESWT (p <0.05) in terms of reduced pain and disintegration of calcification. Conclusion: rESWT has showed positive effects in the treatment of patients that have calcific tendinopathy of the shoulder.