Introduction. Air borne allergens are the most common causes of allergy. They include pollens, house dust mites, animal hair and other animal products. Our study sought to determine which allergens were responsible for allergic diseases in patients seen at the Clinical Center Banjaluka from 2001-2010. Methods. This retrospective population study included 4003 patients, late adolescents and adults. Most patients (63.5%) were female. Their response to aeroallergens was assessed by skin prick tests. Results. Patients were diagnosed most frequently with rhinitis (40.8%) or dermatitis (27.6%); 16.1% had different allergic diagnoses and 15.5% had asthma. More than a third of the cohort (38.3%) responded positively to at least one allergen. The rhinitis group had the greatest number of positive skin prick tests for dust mite (Dermatophagoides pteronyssinus) (24.1%) and weed pollens (18.3%), grass pollens (15.2%), and tree pollens (8.2%). A small number of patients tested positive to animal hair (1.5%), feathers (2.6) and cockroach (2.8%) allergens. Those with other diagnoses were the least responsive. There were no statistically significant differences between groups tested for cockroach (Blatella germanica), feathers and animal hair. Although most patients were female, allergy is more common in men than in women. Conclusion. More than one third of the patients tested had allergic rhinitis. House dust mite (Dermatophagoides pteronyssinus) and weed pollens were the most common aeroallergens for all tested groups.