Sir Editor, The recent report on "angiotensin-converting enzyme (ACE) genetic polymorphism." is very interesting. Albuquerque et al.1 concluded that "the DD genotype was independently associated with worse echocardiographic outcome, while the DI genotype, with best echocardiographic profile." In fact, the polymorphism of ACE is different in different countries and the relationship to clinical disorder is widely mentioned2. The study of ACE polymorphism has proved to be useful in management of cardiac patients, especially for selection of proper cardiac drug3. However, the relationship to cardiac pathology is still controversial. Similar to the present study, the ventricular function abnormality determined by EKG was proposed for interrelationship with ACE polymorphism by Yu Jin et al4. Nevertheless, the small sample size in the published studies1,4 is the main obstacle for conclusions. The effect of race in clinical relationship of ACE polymorphism requires a very large study in order to lead to conclusions2.