ABSTRACT BACKGROUND AND OBJECTIVES: Stress and experiences in nursing activities can cause physical and mental illness, making it important to monitor the health of these professionals. The aim of the study was to assess the frequency and intensity of musculoskeletal pain and the resilience of nursing professionals working in a nephrology unit. METHODS: Cross-sectional, descriptive study, developed with nursing professionals who work in the nephrology unit of a general hospital. For data collection, a sociodemographic, labor and clinical questionnaire, a Nordic musculoskeletal symptom questionnaire, a numerical pain assessment scale and a resilience scale were used. RESULTS: 15 nursing professionals aged between 31 and 40 years participated in the study. Pain intensity was moderate to high in different anatomical regions. The most affected body regions were shoulders, ankles, feet and the dorsal and lumbar region. 40% of participants showed moderate resilience and 33.4% high resilience. There was no association between resilience, sociodemographic and work variables and pain intensity. CONCLUSION: The nursing team working in the nephrology unit deals with musculoskeletal pain in different anatomical areas and presents moderate to high resilience, which helps them to continue performing their functions.