
doi: 10.5920/bjpharm.1160
The pharmaceuticalindustry has a growing interest in continuous manufacturing, particularly forhigh-volume dosage forms such as solid oral tablets. This is driven by the obviousbenefits such as small footprint, batch size flexibility, the relative simplicityof scale-up and process control. Tablets are the most popular solid dosageform, while batch granulation is one of the most often used technologies intablet manufacturing. Using ascorbic acid as a model, we show the possibility ofproducing granules and tablets with a sustained-release profile using threetechnological operations: mixing, continuous melt-granulation, and tabletting.
RS1-441, granulation, Pharmacy and materia medica, tablets, melt-granulation, twin-screw extrusion, melt granulation
RS1-441, granulation, Pharmacy and materia medica, tablets, melt-granulation, twin-screw extrusion, melt granulation
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