The methanol extracts of the various plant parts were screened for anti-oxidant activity by thin layer chromatography using 2,2-diphenyl-1-dipicrylhydrazyl (DPPH) while their in vitro antimicrobial evaluation were determined by agar diffusion method and bioautographic technique using Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Pseudomonas aeruginosa as test organisms; aqueous solvent served as control. The result showed that methanol extracts of the epicarp were found to be stronger against the entire test organisms except E. coli and were also found to possess strong antioxidant activity. The seed from the fruit, stem and root bark of the plant were not active against the entire test organisms. The antimicrobial property shown by the leaf is an evidence of the ethno medicinal uses of the plant. Phytochemical screening of the plant showed the presence of saponins, peptides and sugars. Key words: Cola milleni, 2,2-diphenyl-1-dipicrylhydrazyl (DPPH), Eschreichia coli, Bacillus subtilis, staphylococcus aureus, Pseudomonas aeruginosa, antimicrobial, antioxidant activity.