Mangosteen pericarp has been used for long time as traditional medicine. One of main active ingredient in M. pericarp is xanthone. Xanthone has remarkable effects on cardiovascular health, antiviral and anti-inflammatory. Ultrasonic Assisted Extraction (UAE) was employed to extract xanthone from dried M. pericarp and compared with soxhlet extraction and maceration. The UAE was applied by various temperature (33, 45 and 55°C), amplitude (25, 50 and 75%) and solvent (0, 50 and 95% ethanol) for 1 h extraction time. The conditions for the highest xanthone recovery were determined at temperature 33°C, and 50% ethanol at 50% amplitude, resulting 0.16 mg/g of dried M. pericarp. The Box-Behnken design was applied to investigate the optimum condition of UAE. The optimum conditions from Box-Behnken design to obtain the highest xanthone recovery were determined to be temperature 33°C, amplitude 75 and 80% ethanol. The results presented that for UAE in 0.5 h, soxhlet extraction in 2 h and maceration in 2 h, the extracted xanthones were 0.1760, 0.1221 and 0.0565 mg/g of dried M. pericarp respectively. Key word: Ultrasound assisted extraction (UAE), Mangosteen pericarp, xanthone, maceration.