Faidherbia albida (Del.) A. Chev (mimosoidae) is widely used in African traditional medicine (ATM) formanagement of fever, diarrhoea and human trypanosomiasis. Acute and sub-acute toxicity profiles ofethanolic stem bark extract of F. albida were evaluated in wistar albino rats. The acute toxicity wasstudied using the method of Lorke (1983). In the sub-acute toxicity study, four groups of six rats pergroup were used. The control group (1) received 10 ml normal saline/kg body weight while groups 2, 3and 4 received oral daily doses of 125, 250 and 500 mg extract/kg body weight respectively for 21 days.The effects of the extract on clinical signs, feed and water intake, body weight changes, haematology,plasma biochemical parameters, relative organ weight (ROW) were evaluated. The oral LD50 of theextract was estimated to be greater than 5000 mg/ kg body weight. The extract produced slight increasein body weight of rats given 125 mg extract/kg body weight. However, dose-dependent highlysignificant (P < 0.01) decrease in body weight was observed at 250 and 500 mg/ kg-treated rats in weeks2 and 3 of the study. Feed and water intake was not affected by the treatment. ROW for all organs wasnot affected by the treatment except significant (P < 0.05) increase in the testes of rats treated with 250and 500 mg extract/kg body weight. Although the treatment elicited highly significant (P < 0.01) changesin the levels of the hepatic and some of the haematological parameters, they were within the normalreference range for rats. This study revealed that while the stem bark of the plant may be consideredrelatively safe when used sub-acutely, further investigation is needed to ascertain its effect on the malereproductive system as well as its effect on chronic administration.