The flavonoids hesperetin and hesperidin contained in many citrus plants are Claimed to provide several biological activities including anti-inflammatory, Anti-hepatic fibrosis anti-cancer and melanogenesis. They are also widely used in Cosmetics industries as an active ingredient protecting skin against damages. In this research, hesperidin was isolated from dried orange peel while hesperetin was derived from hesperidin. The other six hesperetin derivatives were designed, synthesized and characteried by using NMR-spectroscop. All compounds were evaluated for antioxidant activity using DPPH radical scavenging assay. S11 displayed the most effective antioxidant activity which has the least IC₅₀ among all synthesized compounds (IC₅₀ = 0.19mM).