Implantation failure refers to the failure of the embryo to reach a stage when an Intrauterine gestational sac is recognized by ultrasonography. From the clinical point of view, it is worthy to note that the term ‘implantation failure’ refers to two different types of situation, those in whom there has never been evidence of implantation (no detectable HCG production) and those who have evidence of implantation (detectable HCG production) but it did not proceed to beyond the formation of a gestational sac visible on ultrasonography. In the present era where the field of ART has been so advanced, the unexplained recurrent implantation failure poses a great challenge. Still there are so much of debates regarding the ideal approach towards these cases that there is no definite evidence based proven approach about dealing with these cases. In this review we have tried to simplify the approach towards RIF cases and to reach to possible conclusion keeping in mind the current treatment options available.