Maxillofacial prosthetics is a subspecialty of Prosthodontics that involves rehabilitating patients with defects or disabilities that are congenital or acquired due to trauma, violence, and gunshot injuries in the head and neck region. Such prostheses replace soft and/or hard tissues and restore aesthetics as well as oral functions. The prostheses can be made from a variety of materials. This chapter elucidates the past, present and future in the scope of materials in maxillofacial prosthetics. From acrylic resins, silicones and its modifications to bioprinting and functional maxillofacial prosthetics, this chapter discusses the current state of the art in this field.