Anthelmintics are a class of drugs used to treat infections caused by helminths, or parasitic worms, which include nematodes (roundworms), trematodes (flukes), and cestodes (tapeworms). These medications work by targeting various biological processes essential for the survival and reproduction of these parasites. Common anthelmintics include albendazole, mebendazole, ivermectin, praziquantel, and pyrantel pamoate. Albendazole and mebendazole inhibit the polymerization of tubulin, impairing glucose uptake and depleting energy stores in helminths. Ivermectin increases the permeability of the parasite's cell membrane to chloride ions, leading to paralysis and death. Praziquantel induces severe spasms and paralysis of the worms' muscles by increasing calcium ion permeability. Pyrantel pamoate acts as a neuromuscular blocker, causing paralysis of the parasites. The choice of anthelmintic depends on the type of helminth infection and its location in the body. Effective treatment not only alleviates symptoms but also prevents the spread of infection and reduces the risk of complications. Continued research and development of anthelmintics are crucial to address emerging resistance and improve global health outcomes