Regional anesthesia in obese patients presents significant challenges due to the high prevalence of comorbidities such as hypertension, diabetes, and obstructive sleep apnea (OSA), which increase the risk of perioperative complications. Additionally, the excess adipose tissue complicates the administration of anesthesia, making it necessary to adjust the technique and dosage of anesthetics to improve safety and surgical outcomes. Obesity, considered a multisystem disease, imposes additional requirements in the management of ventilation, venous access, and effective analgesia.