Context: Effect of sexual relations on mental and physical health has been the concern of the Iranian physicians, over a thousand years ago. Sexual ethics is one of the specific health topics of Iranian medicine archives. From the Iranian medicine point of view, because of different mental and physical differences in human, their sexual power and need for sex is different. It is necessary to observe the normal range, since the sexual indulgence causes different illnesses. Evidence Acquisitions: In Iranian medicine, different variables such as time, location, mental and physical situation, and also various forms of sex are discussed in sexual health. Safe sex not just reduces many mental disorders, but also prevents many neurological, digestive, urinary and genital disorders. Also, sexual indulgence is most harmful for health and causes stiffness, weakness and different diseases; therefore observing moderation in sex, according to the therapeutic characteristics and power, has been emphasized. Results: To have safe sex, it is necessary to consider time, mental, and physical status. Having sex when the stomach is full impairs digestion. Sexual relationship after heavy sports and severe emotional reactions such as anger or sadness, and after diarrhea or blood sampling is harmful. It has been recommended that having sex in temperate weather, and after evacuation of urine and feces, considering necessary arrangements, make the couple reach orgasm. Also, in the Iranian traditional medicine references, specific nutritional and health recommendations have been proposed for the sexually active people. Conclusions: Health care recommendations of Iranian physicians involve precious and new points for the updated scientific communities. Scientific revision of these recommendations can be promising for public health improvement.