Supraglottic Airways (SGAs) are an integral part of anaesthetic care. Since their introduction, several modifications, additions, and variations have been developed and are currently in clinical practice since the last 25 years. Not only are they useful for difficult ventilation during both in-hospital and out-of-hospital difficult airway management, they also act as a conduit for tracheal intubation. The newer or second-generation SGAs have been designed to provide a better seal of the airway and are relatively safer since they allow gastric aspiration. Thus, the SGAs may be the most versatile component in the airway management cart. Existing literature on SGAs tends to focus on first generation SGAs and their use in OT only. However, the scope and use of these devices is vast. Knowledge regarding specific devices and supporting data for their use is of utmost importance to patient’s safety. This chapter addresses various types of commercially available novel SGAs and their use in and out of hospital settings.