Complete blood count is a fairly inexpensive test that is widely used in the clinic. Neutrophils are also one of the most important parameters in complete blood count. They play a critical role in upper respiratory tract infection, as well as in many chronic otolaryngology diseases. It also has widespread uses in otorhinolaryngology practice. There are many publications on neutrophil counts and neutrophil lymphocyte ratios in patients. Neutrophil counts and rates play an important role in the follow-up and prognosis of many important otolaryngology diseases such as bell palsy, sudden hearing loss, allergic rhinitis, chronic otitis media, nasal polyposis, and chronic rhinosinusitis. In this chapter, the importance of neutrophils in these diseases will be discussed with the literature.