Dyslipidemia is defined as an imbalance in the blood lipid profile that can cause many metabolic diseases. Several clinical studies in the past have proven the importance of a proper diet in the prevention and treatment of dyslipidemia. However, the relationship between consumption of a single food like red meat or whole grain with the occurrence of dyslipidemia has been well investigated. But considering the cumulative effect of food patterns can indicate a better image of the relationship between daily food intake and dyslipidemia. It has been proven that following diets like the dietary approach to stop hypertension (DASH) diet and the Mediterranean diet (MD) have been associated with a reduction in inflammatory and lipid markers. In recent years, a new diet based on observing the food pattern of the ancestors and early humans, called the Paleolithic diet (PD), has been researched. The PD is categorized as low-carbohydrate and high-fat diet. It is thought that through increasing ketone bodies and suppressing appetite, it reduces the incidence of metabolic diseases. Studies have also been conducted to find out the relationship between PD and dyslipidemia. Therefore, we decided to collect the results of some of them in this chapter.