Barrier methods of contraception prevent the exchange of bodily fluids such as semen, vaginal and anal secretions, and blood between partners during intercourse. Thus, the primary function of these methods of contraception is pregnancy prevention. Some, such as internal and external condoms, provide protection against sexually transmitted infections (STIs) as well. Barrier methods of contraception include condoms (external and internal), diaphragm, cervical cap, contraceptive gel, spermicide, and contraceptive sponge. Since they are non-hormonal and have no systemic effects, these are alternatives for women who cannot use hormonal contraceptives due to certain medical conditions or medications prescribed. The efficacy of these methods of contraception is contingent on their correct and consistent use. This chapter aims to discuss the various barrier methods, their usage, mechanisms of action, advantages, and disadvantages as well as the comparison of some of these methods to one another.