Over 50 different steroids, including precursors to other steroid hormones, are secreted by the adrenal glands, which are located directly above the kidneys. Aldosterone and hydrocortisone, however, are the two most significant hormonal steroids created by the adrenal cortex. Since aldosterone is too expensive to produce commercially, other semi-synthetic analogues are now used to treat Addison’s disease in its place. Fludrocortisone, for example, greatly increases both salt retention and anti-inflammatory activity when combined with hydrocortisone. The kidneys’ ability to reabsorb sodium is increased by aldosterone. Increased blood volume will follow an increase in plasma sodium concentration. Additionally, aldosterone boosts potassium ion excretion. Addison’s disease is brought on by inconsistency. Glycogen storage synthesis is induced by the synthesis of glycogen synthase, and gluconeogenesis (the production of glucose from glucose) is induced in the liver.