Surgery is one of the most important steps in most of brain tumors management. In this regard, the extent of resection has been considered as an important prognostic factor. However, the resection may be limited by the presence of functional brain tissue around or in the tumor. Preventing functional damage during brain surgery is essential to keep a good postoperative performance status and for facing the successive steps in brain tumor management (i.e., radio- and/or chemotherapy). This chapter will describe all the procedures around an awake surgery for a brain tumor: from presurgical preparation to postoperative treatments and follow-up. It will not focus only on surgical approaches, but also on the specific aspect of the disciplines that are involved in this procedure.