The integration of three different domains: artificial intelligence (AI) and machine learning (ML) and advanced deep learning (DL) algorithms with blockchain and cryptocurrency ecosystems is revolutionizing financial technologies. The “Cryptoeconomics” word born from the intersection of cryptography, economics, and decentralized computation. It has its own importance existing in AI and ML to enhance decision-making, optimize consensus mechanisms, detect fraud, and forecast market trends. This chapter provides the AI and blockchain, highlighting innovations in algorithmic trading, predictive analytics, and security management. This chapter also provides the research gaps, AI and ML applications in cryptoeconomics, technical challenges, and future prospects. And overall, this chapter gives the applications and implementation of ethical concerns, and potential research directions for establishing the intelligent and sustainable cryptoeconomic systems.