Keratoconus is a very frequent disease and is no diagnosed in many cases. Our chapter will focus on the several diagnostic tools not to miss this disease and also will present a all the treatment options with special focus on Corneal Cross Linking. All the indications for this treatment will be analyzed and extensively discussed as it should be considered the only option to stop the progress of the cone. Also, statistical analysis from our clinic with more than 2000 treatments with Cross Linking and follow up since 2006 will be presented. Literature review with results of this treatment is also going to be presented. Finally, a case of keratoconus treated with PRK and follow up of 30 years will be discussed and analyzed as the introduction of the combination of Cross Linking and Wavefront as one very good option in cases of mild to moderate keratoconus.