Challenges to cotton farming in recent scenario of climatic changes can be mitigated by digital innovations and applications in cotton farming. Digital innovations can offer numerous opportunities for sustainability and improved productivity. Technologies including remote sensing, digital information system, and artificial intelligence can boost/redefine crop monitoring and management practices. Implementation of technologies like smart sensors, satellite imaging, management software/machine learning, autonomous machinery can redefine decision making about crop with the higher yield and lower costs of inputs. Environmental impacts of hazardous crop protection chemicals and inefficient use of irrigation water contributes to loss in biodiversity. In a market chain, digital innovations can assist in transparency and traceability to meet consumer demand and sustainability.