Nuclear fusion, the process that powers stars, holds immense potential as a clean and virtually limitless energy source for humanity. Fusion research has evolved into three primary categories: thermonuclear fusion, cold fusion, and advanced fusion methods. Thermonuclear fusion, the most widely studied approach, relies on extreme temperatures (millions of Kelvins) to overcome the Coulomb barrier and achieve fusion in a plasma state. Prominent examples include magnetic confinement fusion (MCF) devices like tokamaks and stellarators, as well as inertial confinement fusion (ICF). In this chapter, plasma confinement methods and the components of a thermonuclear fusion reactor are reviewed. An accelerator-based approach for tritium production is proposed, and novel blanket-related designs are presented. In nuclear physics, the probability of nuclear reactions is expressed by the cross section; therefore, the choice of target and beam for tritium production is defined by a cross section comparison, which is discussed in this chapter.