Pistacia atlantica, a plant native to the Mediterranean region, holds significant traditional medicinal value for various health conditions, notably those associated with inflammation. This study aims to review the existing literature regarding the anti-inflammatory properties of P. atlantica and discuss its potential as an alternative treatment option. An extensive search was conducted using PubMed, Scopus, Web of Science, and Google Scholar databases to identify relevant articles published up until January 2024. Articles were selected based on their relevance to the topic, quality, and credibility. Pistacia atlantica exhibits anti-inflammatory properties, as evidenced by its traditional use in treating conditions like stomach diseases, renal disorders, wounds, coughs, gastrointestinal disorders, and inflammatory diseases. Numerous scientific studies support these claims, demonstrating that P. atlantica possesses antioxidant, anti-inflammatory, and antimicrobial activities. Specifically, it has been observed to alleviate bowel inflammation, inhibit protein denaturation, and exert protective effects against oxidative stress. The strong correlation between the traditional uses of P. atlantica and its proven anti-inflammatory properties suggests that it may serve as an effective natural remedy for inflammatory conditions. However, additional research and clinical trials are required to fully understand its mechanism of action and optimize its therapeutic applications. By exploring the synergy between traditional knowledge and contemporary pharmacological understanding, we hope to contribute to the development of novel treatments for inflammatory diseases.