This chapter aims to provide guidelines on implementing treatment outcome measures (TOMs) in telemedicine. It outlines the definition and the ICF classification of TOMs and highlights the considerations for integrating TOMs in telemedicine. We identified the STEERING model, which guides toward the development of effective TM systems that have the potential to promote TOMs. Furthermore, the chapter provides a roadmap on how to administer TOMs in telemedicine, with an emphasis on facilitators and barriers to this process. Finally, the chapter provides a schematic representation of selected TM systems with and without hardware and highlights the implemented TOMs in the context of the STEERING model and the three-pronged approach.