Propolis is a product derived from bees and consists of a dark coloured sticky material, which is collected from various plants and mixed with wax. Propolis is found coating a thin layer of this substance on the inner walls of their hives in order to repair or protect the hive from invaders. In dentistry, consideration should be given to the large number of medicinal plants and other natural products, including those from the animal kingdom such as propolis, which can make an important contribution to the area of health and be willing to scientifically study their therapeutic properties, so that after verifying their value, they can be introduced more constantly in dental treatments and in some cases replaced definitively due to their properties, especially their biocompatibility, with the aim of massively increasing their application.