Prolonged use of solvents has harmful impacts on the environment, and entire surviving things. One of the most crucial demands of green chemistry is the cutting down of solvent use or substituting with less hazardous ones. Green solvents are explored as an alternative to traditional solvents. They are specified by low toxicity, easy availability re-usability extraordinary efficiency, environmentally friendly reaction medium, non-flammability, increased reactions rate, decrease reaction temperatures as well greater selectivity, and non-volatility. There are numerous applications of green solvents in many industries such as the cosmetic, pharmaceutical industries, chemical industries, perfumery, and also expended to extract crude material, flavonoids, oils and fats, scents and antioxidants, proteins, volatile compounds, and sugars. To get over the properly-hooked up drawbacks of traditional solvents, exquisite extraordinary research attempts have been these days dedicated to the alternative of conventional chemical reaction media using the so-known as green Solvents. In this experience, the selection of a secure, bio-renewable, non-toxic, and reasonably-priced response media is a vital purpose in chemical synthesis. Thus, this special issue on “green solvents” has been aimed to show off a sequence of exhilarating contributions from global researchers within the various sub-regions of chemical synthesis in green solvents.