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InTech
Part of book or chapter of book . 2021
Data sources: InTech
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Part of book or chapter of book
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https://doi.org/10.5772/6804...
Part of book or chapter of book . 2009 . Peer-reviewed
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Use of Constrained Nonlinear Kalman Filtering to Detect Pathological Constriction of Cerebral Arterial Blood Vessels

Authors: Cattivelli, Federico S.; Asgari, Shadnaz; Vespa, Paul; Sayed, Ali H.; Bergsneider, Marvin; Hu, Xiao;

Use of Constrained Nonlinear Kalman Filtering to Detect Pathological Constriction of Cerebral Arterial Blood Vessels

Abstract

Estimation of lumped cerebral arterial radius is important for healthcare monitoring in ICU patients, specially for detecting the presence of vasospasm following Subarachnoid Hemorrhage. A technique for continuous monitoring based on available measurements without introducing any additional invasive technique is very attractive, and would allow detection of vasospasm earlier and more accurately than other methods such as angiography. Our proposed estimation approach uses a combination of parameter estimation and state estimation techniques, and relies heavily on mathematical models of cerebral hemodynamics.We presented two models based on previous work by Ursino et. al, and showed through simulation how a simpler Model 2, with only four state-variables could predict changes in arterial radius from the signals generated through Model 1. We showed how to estimate the parameters of Model 1 through a non-linear least-squares technique, and how we trained the model on the first available recording of every patient. Then we applied our state-estimation approach using DD1 filtering, and a DD1 filter with constraints (QCKF). We showed that our approach detected the presence of vasospasm for Patient A, and observed a radius evolution that matches the expected results. The QCKF produced smaller errors in the output estimation, indicating that constraining the states to be within reasonable limits may improve the accuracy of the estimation. We also estimated the arterial radius for Patient B, which had a constant mild vasospasm throughout the recordings. In essence, we have shown the potential of Kalman-like state-estimators for nonlinear models. This application could potentially save lives by predicting post-SAH vasospasm before other techniques would.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green
hybrid