Future wireless communication systems will require reliable and spectrally efficient transmission techniques to support the emerging high-data-rate applications. The design of these systems necessitates the integration of various recent research outcomes of wireless communication disciplines. So far, the most recent tracks of investigations for the design of the spectrally efficient system are multiple antennas, cooperative networking, adaptive modulation and coding, advanced relaying and cross layer design. The original works of Telatar [1], Foschini [2] and the early idea of Winters [3] as well as the contribution of Almouti[4] stress the high potential gain and spectral efficiency by using multiple antenna elements at both ends of the wireless link. This promising additional gain achieved by using Multiple Input Multiple Output (MIMO) technology has rejuvenated the field of wireless communication. Nowadays this technology is integrated into all recent wireless standards such as IEEE 802.11n, IEEE 802.16e and LTE [5, 6]. The main objective of this chapter is to provide a comprehensive overview of various MIMO Techniques and critical discussion on the recent advances in Multi-user MIMO precoding design and pointing to a new era of the precoding application in WiMAX systems.