The new complex method of seismic hazard assessment that resulted in creation of the probabilistic maps of seismic microzonation is presented in this chapter. To study seismicity and analyze seismic hazard of the territory the following databases are formed: macroseismic, seismologic databases and the database of possible seismic source zones (or potential seismic sources PSS) as well. Using modern methods (over-regional method of IPE RAS Russia) and computer programs (SEISRisk-3 – USA) in GIS technologies there were designed some probabilistic maps of seismic hazard for the Republic North OssetiaAlania in intensity units (MSK-64) at a scale of 1:200 000 with exceedance probability being of 1%, 2%, 5%, 10% for a period of 50 years, which corresponds to recurrence period of 5000, 2500, 1000, 500 years. Moreover, first the probabilistic maps of seismic hazard were made in acceleration units for the territory of Russia. The map of 5% probability is likely to be used for the large scale building, i.e. the major type of constructions, whereas the map of 2% probability should be used for high responsibility construction only. The approach based on physical mechanisms of the source is supposed to design the synthesized accelerograms generated using real seismic records interpretation.