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Part of book or chapter of book
License: CC BY
Data sources: UnpayWall
https://doi.org/10.5772/45596...
Part of book or chapter of book . 2012 . Peer-reviewed
Data sources: Crossref
https://dx.doi.org/10.5772/455...
Other literature type
Data sources: Microsoft Academic Graph
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Molecular Targets of Benzyl Isothiocyanates in Pancreatic Cancer

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 23 Mar 2012 English Publisher:InTech
Authors: Srinivas Reddy; Kartick C.; Sanjay K.;

doi: 10.5772/45596

Molecular Targets of Benzyl Isothiocyanates in Pancreatic Cancer

Abstract

Addiction of cancer cells to survival pathways has been well documented in most of the cancer models including the pancreatic cancer. Pancreatic cancer is one of the most aggressive tumors with an average five year survival rate of less than 5% (Jemal A et al., 2010). It is associated with high expression levels of various survival pathways, such as KRAS, STAT3, AKT, NFkB, HDAC etc. Furthermore, pancreatic cancer acquires resistance to various apoptosis signals such as FasL, TRAIL. In addition, pancreatic cancer gets resistance to various chemo-drugs including gemcitibine by altering survival pathways.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
hybrid
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Cancer Research