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</script>doi: 10.5772/37696
handle: 1959.13/1040149
Early embryonic development is a very precise and complicated process. When a sperm meets an egg, a series of well-orchestrated changes take place, which end up with distinct types of cells that make up an organism. Cells start from a pluripotent state and differentiate without changes in DNA sequence. A differentiated cell shares the same DNA sequence with the zygote from which it is descended (mammalian B and T cells being an exception). The diverse functions of different cells are due to tissue-specific patterns of gene expression, which are established during development; once the fates of the cells are decided, they will be maintained faithfully through cell divisions. Hence it is reasonable to assert that development is, by definition, an epigenetic process (Reik, 2007). The specific gene expression programs in differentiated cells are regulated by a more flexible system, which dynamically switches on and off the genes for maintaining homeostasis or responding to environmental changes.
570, DNA methylation, epigenetics, embryonic development, differentiated cells
570, DNA methylation, epigenetics, embryonic development, differentiated cells
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