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InTech
Part of book or chapter of book . 2012
Data sources: InTech
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
https://cdn.intechopen.com/pdf...
Part of book or chapter of book
License: CC BY
Data sources: UnpayWall
https://doi.org/10.5772/37696...
Part of book or chapter of book . 2012 . Peer-reviewed
Data sources: Crossref
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DNA methylation in development

Authors: Pan, Xin; Smith, Roger; Zakar, Tamas;

DNA methylation in development

Abstract

Early embryonic development is a very precise and complicated process. When a sperm meets an egg, a series of well-orchestrated changes take place, which end up with distinct types of cells that make up an organism. Cells start from a pluripotent state and differentiate without changes in DNA sequence. A differentiated cell shares the same DNA sequence with the zygote from which it is descended (mammalian B and T cells being an exception). The diverse functions of different cells are due to tissue-specific patterns of gene expression, which are established during development; once the fates of the cells are decided, they will be maintained faithfully through cell divisions. Hence it is reasonable to assert that development is, by definition, an epigenetic process (Reik, 2007). The specific gene expression programs in differentiated cells are regulated by a more flexible system, which dynamically switches on and off the genes for maintaining homeostasis or responding to environmental changes.

Country
Australia
Keywords

570, DNA methylation, epigenetics, embryonic development, differentiated cells

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
5
Average
Average
Average
Green
hybrid