Lymphedema is the accumulation of interstitial fluid within tissues due to the impairment of lymphatic function. Dysfunction can result from direct obstruction of lymphatic vessels, absence of lymphatic vessels, or inadequate lymphatic function. From congenital forms of lymphedema, such as Milroy disease, to acquired forms of lymphedema, such as filiarisis lymphedema or post-surgical lymphedema, lymphatic dysfunction contributes significantly to the world’s human disease burden.