Focal segmental glomerulosclerosis (FSGS) as the name implies is a histopathological pattern of lesions, where the “focal” refers to, involving minority of glomeruli and the “segmental” refers to, involving a portion of the glomerular capillary tuft caused by injury to podocytes (Fig 1A). Clinically it manifests proteinuria which can progress to nephrotic syndrome and eventually to end stage renal failure.