During the last few decades accumulated epidemiological, clinical, and experimental evidence has revealed the important role of human papillomavirus (HPV) in the development of cervical carcinomas, an association almost unique in cancer epidemiology. Several important questions have been answered and a large number of scientific studies have paved the way for the introduction of new and effective vaccines, which will hopefully diminish the incidence of HPV-related carcinomas and precursor lesions in forthcoming years (Crum et al., 2003; zur Hausen, 1977, 2008). However, the exact recognition and proper treatment of clinically important lesions often poses problems both to pathologists and gynecologists.