Mechanosensation is a fundamental process in biology and may have been developed by the early cells in response to hypo-osmotic stress [1]. With the evolution of different cell types and the appearance of multi-cellular organisms the mechanisms of mechanosensation and the corresponding transmission of signals became more complex and evolved in different cell types differently [2]. Particularly in cardiac myocytes different mechanosensory protein complexes can be found: i) cell membrane associated ii) intracellular embedded iii) sarcomere related (figure 1). All these various signalosomes are sensitive to different types of mechanical signals. For example, a deformation of the cell membrane may be detected by cell membrane associated signalosomes, such as stretch activated channels (SAC), angiotensin receptors, the caveolae, and integrin mediated signalling. Depending on severity and duration, these events may also be sensed by intermediate filaments (IF) and or even by the sarcomere associated signalosomes. However it is important to differentiate between different types of stresses, such as the normal “stress” () which is physically defined by: